The study aimed to investigate the relationship between individual cardiovascular risk factors and vascular aging in midlife. Over a 30-year period, data from 2180 participants were analyzed, identifying distinct trajectories of systolic blood pressure (SBP), body mass index (BMI), and heart rate (HR) from childhood to midlife. Persistently-increasing SBP, high-increasing BMI, and high-stable HR were associated with increased vascular aging indicators. These associations remained significant even after adjusting for cardiovascular risk factors at the time of assessment. The findings emphasize the importance of addressing risk factors early in life to prevent cardiovascular disease in later stages.